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目的探讨小鼠子宫内膜或蜕膜芸豆凝集素的受体在正常性周期和不同妊娠时期的表达模式。方法应用异硫氰酸荧光素(FITC)标记的芸豆凝集素作为分子探针,通过组织切片检测小鼠不同动情周期以及妊娠过程中子宫内膜或蜕膜芸豆植物凝集素受体的分布和变化规律。结果芸豆凝集素受体广泛存在于小鼠子宫内膜中,且在动情周期,不同妊娠时期受体的表达存在着差异。在围着床期,特别是妊娠4d芸豆凝集素受体较多分布于子宫腔周围和内膜基质部分;妊娠晚期、动情周期和间情期分布于内膜基质且数量较少结论芸豆凝集素受体与胚泡着床和妊娠的维持密切相关。
Objective To investigate the expression patterns of mouse endometrium or decidual kidney lectin receptor during normal cycle and different pregnancy stages. Methods FITC labeled kidney bean lectin was used as a molecular probe to detect the distribution and changes of lectin receptors in endometrium or deciduous kidney bean during different estrous cycles and during pregnancy law. Results kidney bean lectin receptor widespread in the mouse endometrium, and in the estrous cycle, there are differences in the expression of the receptor during pregnancy. In the perinatal period, especially in pregnancy 4d kidney lectin receptors are more distributed around the uterine cavity and the endometrial stroma; late pregnancy, estrous cycle and estrogen distribution in the intima matrix and the number of less Conclusions Kidney bean agglutinin Receptors are closely related to embryo implantation and pregnancy maintenance.