论文部分内容阅读
Thy-1抗原(原称θ抗原)是小鼠T细胞的一个重要的表面抗原,同时又是区分小鼠T和B淋巴细胞的特异表面标记。研究表明,Thy-1抗原还广泛地存在于包括人类在内的多种动物的脑及其他一些组织中。目前,Thy-1抗原分子已从淋巴细胞和脑组织中提纯,并对其生化特性、化学组成以及结构与功能进行了深入的研究。Thy-1抗原在分布上以及化学结构上,具有许多其他细胞膜蛋白所没有的特点,这引起了许多学者的重视。本文简要地介绍有关Thy-1抗原研究的一些进展。一、Thy-1抗原的发现五十年代末,淋巴细胞的免疫学功能已逐步明确。1961年,胸腺功能的发现使人们开始认识到,淋巴细胞是一个不均一的细胞群,它至少可以分为二类:一类是B淋巴细胞,担负着机体的体液免疫功能(分泌抗体);另一类是T淋巴细胞,担负着机体的细胞免疫功能。 1963年,Boyse等在研究小鼠白血病细胞的表面抗原时偶然发现,一些小鼠的胸腺
Thy-1 antigen (formerly known as θ antigen) is an important surface antigen of mouse T cells and is also a specific surface marker that distinguishes mouse T and B lymphocytes. Studies have shown that Thy-1 antigen is also widely found in many animals, including humans, the brain and other tissues. Currently, Thy-1 antigen molecules have been purified from lymphocytes and brain tissue, and their biochemical characteristics, chemical composition and structure and function of the in-depth study. Thy-1 antigen in the distribution and chemical structure, with many other cell membrane proteins do not have the characteristics, which attracted the attention of many scholars. This article briefly introduces some advances in Thy-1 antigen research. First, the discovery of Thy-1 antigen The late fifties, lymphocyte immunological function has been gradually clear. In 1961, the discovery of thymic function led people to come to realize that lymphocytes are a nonuniform cell population that can be divided into at least two categories: one is B lymphocyte, which is responsible for humoral immune function (secreting antibody) of the body; The other is T lymphocytes, responsible for the body’s cellular immune function. In 1963, Boyse et al., Occasionally found that when studying the surface antigens of mouse leukemia cells, the thymus of some mice