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目的 仿造人类囊状动脉瘤(SA),研究其发生发展及成像诊断技术。方法 取兔颈总动脉(CCA),用吻合一段颈内或颈外静脉,造成静脉囊(VP)法,制成单侧型、分叉型及末梢型SA,3周后行彩色多普勒超声(彩超)、磁共振血管成像(MRA)和数字减影血管造影(DSA)或造影检测。结果 CCA壁梭形切口较直切口形成SA的成功率高,DSA和MRA二者结合可提高SA的诊断率。模型的血液动力学决定于SA与载瘤CCA的角度,涡流是影响其发展的主要因素。结论 该模型在分型、血液动力学改变方面类似于人颅内SA,可用于研究其血液动力学和各种治疗方法
Objective To imitate the human saccular aneurysm (SA), study its occurrence and development and imaging diagnostic techniques. Methods Rabbit common carotid artery (CCA) was obtained. The anastomosed carotid artery or internal jugular vein was used to make the venous sac (VP) method. Unilateral, bifurcated and peripheral SA were made. After 3 weeks, the color Doppler echocardiography Ultrasound), magnetic resonance angiography (MRA) and digital subtraction angiography (DSA) or contrast detection. Results The success rate of the CCA fusiform-shaped incision compared with the straight incision was high. The combination of DSA and MRA could improve the diagnostic rate of SA. The hemodynamics of the model is determined by the angle of SA and tumor-bearing CCA, which is the major factor affecting its development. Conclusions This model is similar to human intracranial SA in typing and hemodynamic changes and can be used to study its hemodynamics and various therapies