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目的探讨了消化性溃疡患者治疗前后血清胃泌素水平与NO、NOS水平的关系。方法应用放射免疫分析法和化学法对32例消化性溃疡患者进行了治疗前后血清胃泌素、NO、NOS水平检测，并与35例正常健康人作比较。结果消化性溃疡患者在治疗前血清胃泌素水平非常显著地高于正常人组（P<0.01），而血清N O、N O S水平又非常显著地低于正常人组（P0.05），血清胃泌素水平与N O、NOS水平呈显著负相关（γ=-0.4925，-0.5136，P<0.01）。结论消化性溃疡的发生与发展可能与胃泌素、NO、NOS水平有关。“,”Objective:To study the relationship between of Serum GS and NO、NOS levels after treatment in patients with peptic ulcer. Methods: SerumGS(With RIA) Serum NO、NOS (With Chemistry) levels were measured in 32 patients with peptic ulcer and 35 Controls. Results:Before treatment Serum GS levels were significantly higher than those in Controls (P<0.01), but Serum NO、NOS levels were significantly lower (P 0.05),Serum GS levels were negatively correlated with Serum NO、NOS levels(γ=-0.4925,-0.5136,P<0.01). Conclusions:There may exisct the relationship between the Serum GS、NO、NOS levels and occurrence and development of peptic ulcer.