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目的 探讨急性柯萨奇病毒性心肌炎 (ACM)患者体内的氧化应激。方法 采用分光光度分析法检测 50例ACM患者和 50例健康志愿者 (对照组 )的血浆谷胱甘肽_S_转移酶 (GST)和过氧化脂质 (LPO)值及红细胞谷胱甘肽过氧化物酶 (GPX)和过氧化脂质 (LPO)值。结果 与对照组比较 ,ACM患者组的血浆LPO和红细胞LPO平均值显著升高 (P <0 0 1～ 0 0 0 1) ,而血浆GST和红细胞GPX平均值显著降低 (P <0 0 0 1) ;ACM患者随着GST值的降低 ,血浆LPO和红细胞LPO值逐渐升高 (P <0 0 1～ 0 0 0 1) ,而红细胞GPX值逐渐降低 (P <0 0 0 1) ;ACM患者遭受潜在氧化损伤的危险度至少是对照组的 2 2倍 ,而最大可达 139 8倍。结论 ACM患者体内一系列自由基连锁反应加剧 ,从而引起了严重的氧化应激和潜在的氧化损伤
Objective To investigate the oxidative stress in patients with acute coxsackievirus myocarditis (ACM). Methods The levels of plasma glutathione S-transferase (GST) and lipid peroxidation (LPO) in 50 ACM patients and 50 healthy volunteers (control group) were measured by spectrophotometry. The levels of glutathione Peroxidase (GPX) and Lipid Peroxide (LPO) values. Results Compared with the control group, the average values of LPO and erythrocyte LPO were significantly increased in patients with ACM (P <0.01-0.01), while the average values of plasma GST and erythrocytes were significantly decreased (P <0.01 ). With the decrease of GST value, the LPO values of LPO and erythrocytes in ACM patients gradually increased (P <0.01-0.01), while the GPX values of erythrocytes decreased (P <0.01). In ACM patients The risk of underlying oxidative damage is at least 2 2 times greater than that of the control group and up to 139 8 times. Conclusion ACM patients with a series of free radical chain reaction intensified, causing serious oxidative stress and potential oxidative damage