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０．１～２．５ｍｇ·Ｌ－１白芍总甙（ＴＧＰ）对正常人的ＬＰＳ诱导外周血单个核细胞产生ＩＬ－１．ＰＨＡ－Ｐ诱导淋巴细胞增殖反应和ＩＬ－２产生均呈现浓度依赖性的双向作用；ＴＧＰ还可浓度（０．１～１２．５ｍｇ·Ｌ－１）依赖性地降低正常人淋巴细胞上ＩＬ－２Ｒ的密度．ＴＧＰ能使类风湿性关节炎（ＲＡ）患者低下的ＰＨＡ－Ｐ致分裂素反应与ＩＬ－２产生能力恢复正常，使外周血中减少的Ｔｓ细胞数目回到正常水平．但可使ＲＡ患者ＰＢＭＣ过度产生ＩＬ－１降低至正常范围．并能显著降低ＲＡ患者增高的淋巴细胞ＩＬ－２Ｒ的密度。上述结果表明．ＴＧＰ对ＲＡ患者有明显的机能依赖性免疫调节作用．ＴＧＰ对ＲＡ的治疗作用可能与其调整ＲＡ患者异常的免疫功能有关。
0.1 ~ 2.5mg · L-1 paeony glycoside (TGP) on normal human LPS-induced peripheral blood mononuclear cells to produce IL-1. PHA-P induced lymphocyte proliferation reaction and IL-2 production in a concentration-dependent bidirectional effect; TGP also concentration (0.1 ~ 12.5mg · L-1) dependently reduce the normal human lymphocytes IL- 2R density. TGP normalizes hypohalogenic PHA-P mitogen response and IL-2 production in patients with rheumatoid arthritis (RA), reducing the number of Ts cells in the peripheral blood back to normal. However, RA patients with PBMC overproduction of IL-1 decreased to the normal range. And can significantly reduce the elevated lymphocyte IL-2R density in patients with RA. The above result shows. TGP has a clear function-dependent immunomodulatory effect on RA patients. The therapeutic effect of TGP on RA may be related to its regulation of abnormal immune function in RA patients.