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1970年始,省中西医结合研究院(原省中医药研究所)与省药品检验所、省医学科学研究所、济南人民制药厂等单位协作,对男用口服避孕药进行了研究。从棉籽仁中分离出棉酚,并用实验证实棉酚是抗生育的有效成分。随后又对合成的一系列棉酚衍生物进行筛选。经过几年的实验和临床研究,排除“四人帮”的干扰破坏,终于研制出一种新的非激素类男用口服避孕药一甲酸棉酚。甲酸棉酚(C_(31)H_(32)O_(10))为微酸、无
Since 1970, the Provincial Institute of Chinese Integrative Medicine (formerly the Provincial Institute of Traditional Chinese Medicine) has collaborated with the Provincial Institute for Drug Control, Provincial Institute of Medical Sciences, Jinan People’s Pharmaceutical Factory and other units to study male oral contraceptives. Gossypol was isolated from cottonseed kernels and confirmed by experiments that gossypol is an effective anti-fertility ingredient. A series of synthetic gossypol derivatives were subsequently screened. After several years of experimental and clinical research to rule out the “gang of four,” the interference and destruction, and finally developed a new non-hormonal male oral contraceptives, a formic acid gossypol. Formic acid gossypol (C_ (31) H_ (32) O_ (10)) is slightly acidic, none