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氯普噻吨本身不具有荧光 ,但氧化后可形成具有强荧光的产物 .本文系统地研究了以稀硝酸为氧化剂对氯普噻吨的氧化作用 ,提出了高灵敏度测量氯普噻吨的荧光光度分析新方法 .结果表明 :荧光强度与氯普噻吨的浓度在 0 .0 0 4～ 0 .1m g/ L范围内呈良好的线性关系 .该法简便 ,快速 ,灵敏度高 ,检出限可达 0 .0 0 2 mg/ L(6 .33× 10 - 9mol/ L) ,利用该法测量片剂中氯普噻吨的含量 ,结果令人满意 ,平均回收率为 99.6 % .
Chlorpheniramine itself does not have fluorescence, but the oxidation can form a product with strong fluorescence.This paper systematically studied the dilute nitric acid as oxidant chlorphethetiton oxidation, proposed a high sensitivity chlorphentin fluorescence A new method of photometric analysis was established.The results showed that the fluorescence intensity showed a good linear relationship with the concentration of chlorprothixene in the range of 0.004-0.1m g / L, which was simple, rapid, sensitive and the detection limit Up to 0.002 mg / L (6.33 × 10 - 9mol / L). The method was applied to the determination of chlorprothixene in tablets with satisfactory results with an average recovery of 99.6%.