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目的对比两种不同药物方案治疗女性贫血的临床疗效和不良反应。方法回顾性分析2013年6月-2016年10月杭州市第一人民医院门诊收治的191例女性贫血患者,根据治疗药物分成琥珀酸亚铁组和多糖铁复合物组。不同方法治疗后,比较两组的临床疗效血清血红蛋白(Hb)、红细胞(RBC)变化,观察不良反应发生情况。结果琥珀酸亚铁组和多糖铁复合物组的临床总有效率分别为92.78%和82.98%,差异有统计学意义(P<0.05);治疗后2周、4周,琥珀酸亚铁组血清Hb、RBC明显高于多糖铁复合物组(P<0.05);琥珀酸亚铁组的胃肠道不良反应发生率明显高于多糖铁复合物组(P<0.05)。结论琥珀酸亚铁提高了女性贫血临床治疗的总有效率,促进了血清Hb、RBC的恢复,但对胃肠道有一定的刺激,临床中应根据患者特点选择治疗方案。
Objective To compare the clinical efficacy and side effects of two different drug regimens in the treatment of female anemia. Methods A retrospective analysis of 191 female patients with anemia who were admitted to First People’s Hospital of Hangzhou from June 2013 to October 2016 was divided into two groups according to the therapeutic drugs, namely, ferrous succinate group and polysaccharide iron complex group. After the different treatment methods, the clinical curative effect of serum hemoglobin (Hb) and erythrocyte (RBC) were compared between two groups to observe the occurrence of adverse reactions. Results The total clinical effective rates of the ferrous succinate group and the polysaccharide iron complex group were 92.78% and 82.98%, respectively, with statistical significance (P <0.05). After 2 and 4 weeks of treatment, the serum ferrous succinate group Hb and RBC were significantly higher than that of polysaccharide-iron complex (P <0.05). The incidence of gastrointestinal adverse reactions in ferrous succinate group was significantly higher than that of polysaccharide-iron complex group (P <0.05). Conclusion Ferrous succinate increased the total effective rate of clinical treatment of female anemia and promoted the recovery of serum Hb and RBC. However, it had some stimulation to the gastrointestinal tract. The clinical treatment should be based on the characteristics of the patients.