组织坏死后矿(钙)化是甲状腺癌病灶中普遍存在的钙化形式之一,与病变关系密切。利用光学显微镜、环境扫描电镜、高分辨透射电镜及显微红外光谱研究了6例甲状腺乳头状癌中的组织坏死后矿化特征。结果表明,组织坏死后矿化往往发生在胶原纤维丰富的位置,与胶原关系密切。矿化表现出2种形态,矿(钙)化灶内为较为致密的隐晶集合体,其表面及其附近的胶原上沉淀有许多微米级矿化小球,离矿化灶较远的胶原纤维上也散布有矿化小球。一些矿化小球边缘还发育絮状矿化物质,使之形成绒球状外貌。矿化物质结晶程度均较差,由纳米多晶组成。钙化灶中央较致密部分的n(Ca)/n(P)比较高,接近羟基磷灰石的理论比值,而其边缘以及矿化小球的n(Ca)/n(P)比均较低,可能含有磷酸八钙等低n(Ca)/n(P)磷酸钙系列矿物。矿化初期形成纳米多晶组成的微米级矿化小球,矿化小球逐渐聚集形成大面积的矿化灶。 Tissue necrosis after mineralization (calcium) is a common calcification in thyroid lesions one of the forms, and lesions are closely related. The mineralization characteristics of tissue after necrosis in 6 thyroid papillary carcinomas were studied by optical microscopy, environmental scanning electron microscopy, high resolution transmission electron microscopy and microscopic infrared spectroscopy. The results show that mineralization after tissue necrosis often occurs in rich collagen fibers, which is closely related to collagen. Mineralization showed two kinds of morphology, mineral (calcium) within the stove for the more dense cryptocrystalline aggregates, the surface and near the collagen deposition of many micron mineralized pellets, far away from the mineralization of collagen Mineral fibers are also scattered on the ball. Some of the mineralized pellets also develop flocculent mineralization on the edge of the pellets to form a pompom-like appearance. Mineralization degree of crystallization are poor, composed of nano-polycrystalline. The n (Ca) / n (P) of the denser part of calcification center was higher than that of hydroxyapatite, and the ratio of n (Ca) / n (P) at the edge and mineralized pellets was lower , May contain low n (Ca) / n (P) calcium phosphate minerals such as octacalcium phosphate. At the initial stage of mineralization, micron-sized mineralized spheres formed by nano-polycrystal are formed, and the mineralized spheres gradually gather to form a large area of ​​mineralized spheres.