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目的探讨和比较WU多瘤病毒(WUPyV)以及呼吸道合胞病毒(RSV)所致呼吸道感染患儿的临床特征。方法应用多重PCR技术,检测呼吸道感染住院患儿WUPyV、RSV等病毒感染情况,并收集WUPyV和RSV感染患儿的临床资料。结果 2008年1月至2010年9月,在1 701例呼吸道感染住院患儿的咽拭子标本中检测出WUPyV阳性46例(2.7%),RSV阳性365例(21.5%);单纯WUPyV感染为22例(47.8%),单纯RSV感染为88例(24.1%)。RSV感染患儿的合并感染率高于WUPyV感染患儿,两者差异有统计学意义(χ2=11.723,P=0.001)。WUPyV阳性检测率在春季呈现高峰,RSV则在冬季。WUPyV感染患儿的中位年龄为26.2个月,RSV感染患儿为14.9个月,两者差异有统计学意义(U=669.5,P<0.05)。WUPyV感染患儿的临床表现和体征与RSV感染相似,咳嗽(χ2=13.34,P<0.001)和喘息(χ2=10.53,P<0.001)在RSV感染的患儿中更为多见。WUPyV感染后主要被诊断为支气管肺炎,而RSV感染后主要为毛细支气管炎。单纯RSV感染患儿更多需要激素治疗(χ2=9.321 P=0.002)。结论部分患儿呼吸道感染与WUPyV感染有关,WUPyV感染的临床特征与RSV感染类似。
Objective To investigate and compare the clinical features of children with respiratory tract infection caused by WUPyV and RSV. Methods Multiplex PCR was used to detect the prevalence of WUPyV and RSV in hospitalized children with respiratory tract infection, and the clinical data of WUPyV and RSV infected children were collected. Results From January 2008 to September 2010, 46 (2.7%) were positive for WUPyV and 365 (21.5%) were positive for throat swab from 1 701 hospitalized children with respiratory tract infection. The WUPyV infection was 22 cases (47.8%), simple RSV infection was 88 cases (24.1%). The infection rate of children with RSV infection was higher than that of WUPyV infection, the difference was statistically significant (χ2 = 11.723, P = 0.001). WUPyV positive detection rate peaked in spring, RSV in winter. The median age of WUPyV infection was 26.2 months and that of RSV infection was 14.9 months. The difference was statistically significant (U = 669.5, P <0.05). Clinical manifestations and signs in children with WUPyV infection were similar to those with RSV infection. Cough (χ2 = 13.34, P <0.001) and wheeze (χ2 = 10.53, P <0.001) were more common in children with RSV infection. WUPyV infection is mainly diagnosed as bronchopneumonia, while the main infection after RSV bronchiolitis. Children with RSV alone required more hormone therapy (χ2 = 9.321 P = 0.002). Conclusion Some children with respiratory tract infection are related to WUPyV infection. The clinical features of WUPyV infection are similar to those of RSV infection.