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目的:比较氯化两面针碱固体脂质纳米粒和氯化两面针碱在大鼠体内的药动学。方法:12只Wistar大鼠随机分为2组,分别按剂量10mg/kg注射氯化两面针碱固体脂质纳米粒和氯化两面针碱,用高效液相法测定各时间点血药浓度,计算并分析药动学参数。结果:氯化两面针碱固体脂质纳米粒、氯化两面针碱T1/2分别为(276.9393±7.9606)、(163.519±9.9019)min;Cl(s)分别为(0.0599±0.0011)、(0.2037±0.0100)L.min/kg;AUC(0-t480)分别为(167.0805±3.2012)、(49.1851±2.3818)μg.min/ml。结论 :氯化两面针碱固体脂质纳米粒与氯化两面针碱相比,具有长效和缓释的特点。
OBJECTIVE: To compare the pharmacokinetics of Nitramisia spinosiuri solid lipid nanoparticles and nitidine chloride in rats. Methods: Twelve Wistar rats were randomly divided into two groups. The rats were anesthetized with 10 mg / kg injection of nitidine chloride solid lipid nanoparticles and nitidine chloride respectively. The plasma concentration of each drug was measured by HPLC. Calculate and analyze pharmacokinetic parameters. Results: The results showed that T1 / 2 was (276.9393 ± 7.9606), (163.519 ± 9.9019) min and Cl (s) were (0.0599 ± 0.0011) and ± 0.0100) L.min / kg; AUC (0-t480) were (167.0805 ± 3.2012) and (49.1851 ± 2.3818) μg.min / ml, respectively. Conclusion: Nitidine chloride solid lipid nanoparticles have long-term and slow release characteristics compared with nitidine chloride.