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目的观察糖皮质激素联合甲氨蝶呤治疗多发性肌炎与皮肌炎的临床效果。方法选取医院收治的多发性肌炎和皮肌炎患者53例,随机分为观察组27例和对照组26例。对照组采用糖皮质激素治疗,观察组在对照组基础上联合甲氨蝶呤治疗。比较2组临床疗效、酶学指标变化及不良反应发生情况。结果观察组总有效率为96.3%,高于对照组的76.9%(P<0.05);2组治疗后天冬氨酸氨基转移酶(AST)、谷氨酸氨基转移酶(ALT)、肌酸激酶(CK)和乳酸脱氢酶(LDH)均较治疗前降低,且观察组低于对照组(P<0.05);观察组不良反应发生率为11.1%,低于对照组的34.6%(P<0.05)。结论糖皮质激素联合甲氨蝶呤治疗多发性肌炎和皮肌炎临床疗效确切,患者临床症状、体征均获明显改善,且不良反应发生率低。
Objective To observe the clinical effect of glucocorticoid combined with methotrexate in the treatment of polymyositis and dermatomyositis. Methods Fifty-three patients with polymyositis and dermatomyositis admitted to hospital were randomly divided into observation group (n = 27) and control group (n = 26). The control group was treated with glucocorticoid. The observation group was treated with methotrexate on the basis of the control group. The clinical curative effect, changes of enzymology index and incidence of adverse reactions were compared between the two groups. Results The total effective rate in the observation group was 96.3%, which was higher than that in the control group (76.9%, P <0.05). After treatment, the aspartate aminotransferase (AST), glutamate aminotransferase (ALT), creatine kinase (CK) and lactate dehydrogenase (LDH) in the observation group were lower than those in the control group (P <0.05). The incidence of adverse reactions in the observation group was 11.1%, which was lower than that in the control group (34.6%, P < 0.05). Conclusions Glucocorticoids combined with methotrexate are effective in the treatment of polymyositis and dermatomyositis. The clinical symptoms and signs of patients have been significantly improved, and the incidence of adverse reactions is low.