论文部分内容阅读
复习1940～1989年在Mayo Clinic治疗的全部乳头状甲状腺癌(PTC)患者的记录.由一不知疾病结果的内分泌病理医生按WHO1988年标准将全部病理切片重新检查和分类.平均随访期存活者12.7年,死亡者11.6年.因PTC死亡83例(4.7%).可能预示PTC存活的被检查变量(手术时)包括:性别、年龄、头颈部放疗史、甲亢或桥本氏甲状腺炎、肿瘤大小、颈淋巴结阳性、远处转移、邻近组织甲状腺外浸润、充分手术、多中心灶、滤泡形成度、肿瘤周围间质甲状腺炎、侵犯血管和肿瘤包裹.全组分为二个25年期,1940～1964(764例,死亡55例)和1965～1989(1015例,死亡28例).用标准存活分析评价首次手术后特定时间PTC病人存活百分率并行曲线比较.用Cox比例危害模型行多因素预后分析.用R统计评价不同模型预测死亡时间的能力.
Review the records of all papillary thyroid cancer (PTC) patients treated at the Mayo Clinic from 1940 to 1989. All pathological sections were re-examined and classified according to the WHO 1988 standard by an endocrinologist who did not know the disease outcome. The average follow-up period survivors were 12.7. In the year, the death was 11.6 years. 83 cases (4.7%) died due to PTC. The examined variables (at the time of surgery) that may indicate PTC survival include: gender, age, head and neck radiotherapy history, hyperthyroidism or Hashimoto’s thyroiditis, tumors Size, cervical lymph node positive, distant metastasis, adjacent tissue extrathyroidal infiltrates, adequate surgery, multiple foci, follicular formation, interstitial stromal thyroiditis, encroachment on blood vessels, and tumor entrapment. Full component for two 25-year periods , 1940 to 1964 (764 cases, 55 deaths) and 1965 to 1989 (1015 cases, 28 deaths). Survival analysis was used to evaluate the survival percentage of PTC patients at the specific time after the first operation. Comparison curves. Prognostic analysis of factors. The use of R statistics to evaluate the ability of different models to predict the time of death.