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前几年发表的关于银屑病的报告中,用碳酸锂治疗激发或加剧银屑病的数目多了。碳酸锂使多形核白细胞移行试验导致的皮损增加引起表皮增生,它抑制腺甙酸环化酶的活性,降低了循环中一磷酸腺甙的水平,循环中一磷酸腺甙下降直接与表皮增生有关,也提高了多形核白细胞的活动力和吞噬力。Frolich等注意用消炎痛(一种前列腺素合成酶抑制剂)的患者血浆锂浓度升高,这是因为肾廓清锂的减少,可能依靠前列腺素的机理加以调节。
A few years ago in the report on psoriasis, the use of lithium carbonate to stimulate or aggravate the number of psoriasis more. Lithium carbonate to polymorphonuclear leukocyte migration test results in increased skin lesions caused by epidermal hyperplasia, which inhibits the activity of adenyl cyclase, reducing the level of circulating adenosine monophosphate, cyclic adenosine monophosphate decreased directly with the epidermis Hyperplasia, but also improve the activity of polymorphonuclear leukocytes and phagocytic power. Frolich et al. Noted that patients with indomethacin, a prostaglandin synthetase inhibitor, had elevated plasma lithium concentrations due to the reduction of lithium clearance in the kidney and may be regulated by the mechanism of prostaglandin.