莱姆病由伯氏疏螺旋体(Bb)引起,经蜱媒传播。临床上将此病分为3期:早期出现的慢性游走性红斑具有诊断价值,但不到一半的病人有该体征;二三期病人可出现关节炎、心脏和神经异常。莱姆病的诊断主要靠实验室,包括早期IgM抗体及后来抗Os-pC、OspA、OspB蛋白IgG抗体的检测,但许多感染病人可保持数月血清学阴性,甚至在更长的病程内不产生抗体;分离培养病原 Lyme disease is caused by Borrelia burgdorferi (Bb) and is transmitted by tick media. Clinically, the disease is divided into three phases: the early appearance of chronic migratory erythema has diagnostic value, but less than half of the patients have the signs; two or three patients may have arthritis, cardiac and neurological abnormalities. Lyme disease is diagnosed mainly in the laboratory, including early IgM antibodies and subsequent detection of anti-Os-pC, OspA, OspB IgG antibodies, but many infected patients can remain seronegative for several months even over a longer duration Produce antibodies; isolated and cultured pathogen