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作者根据花斑癣病原菌(环状糠疹芽孢菌Pityrosporum ovale PO),可以引起色素脱失,进一步研究证实从PO中分离出其脂质组分(主要为杜鹃花酸)对酪氨酸酶有竞争性抑制作用,抑制的结果导致色素脱失.在初步治疗20例黄褐斑获得良好褪色作用后,即用以治疗20例恶性雀斑样痣,也得到良好效果.在上述研究工作的基础上观察了杜鹃花酸对黑素瘤的生物学作用.开始用于原发性皮肤恶性黑
According to the pathogen of tinea versicolor (Pityrosporum ovale PO), the authors can cause depigmentation. Further studies have confirmed that the lipid component (mainly azelaic acid) isolated from PO is related to tyrosinase. Competitive inhibition, inhibition of the results lead to pigment loss. In the initial treatment of 20 cases of chloasma obtained good fading effect, that is used to treat 20 cases of malignant lentigo fluorene-like stings, also got good results. Based on the above research work Observed the biological effects of azelaic acid on melanoma. Began to be used for primary malignant black skin