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采取“门静脉部分结扎术”制得的动物模型及门脉高压症患者的脾脏及脾静脉组织块，并以正常大鼠及外伤性脾破裂脾切除患者作为对照，分别送光、电镜观察。旨在探讨门脉高压时内脏血管的病理性损伤与其发病机制的关系。结果表明，与正常对照组相比，门脉高压大鼠及患者脾血窦显著扩张，纤维结缔组织增生。脾静脉壁增厚，平滑肌增生，血管内皮广泛受损。结果提示，门脉高压时内脏血管发生继发性反应性结构改建，对门脉高压血流动力学进一步产生不良影响。
The model of spleen and splenic vein in patients with portal hypertension was established by animal model of “partial portal vein ligation”. The normal rats and patients with splenic resection of traumatic splenic rupture were taken as controls, and were respectively sent to light and electron microscope for observation. To explore the relationship between pathological injury of visceral blood vessels and its pathogenesis in patients with portal hypertension. The results showed that, compared with the normal control group, the splenic sinusoids in portal hypertension rats and patients were significantly expanded, fibrous connective tissue hyperplasia. Splenic vein wall thickening, smooth muscle hyperplasia, extensive vascular endothelial damage. The results suggest that visceral angiogenesis secondary to reactive structural remodeling of portal hypertension, portal hypertension hemodynamics further adversely affected.