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目的 探讨低浓度混苯暴露对早早孕丢失 (EFL)的影响。方法 选择某石化企业有混苯接触的女工 42人为暴露组、无混苯接触的女工 49人为内对照组、某化纤企业无混苯暴露的女工 118人为外对照组 ,自不采取避孕措施的第一个月经周期起留取每日晨尿 ,分别收集到 96、14 6和 435个周期共 15 0 84份尿样 ,用免疫放射法 (IRMA)测定尿液中人绒毛膜促性腺激素 (β hCG)的含量 ,并对早早孕丢失进行评价。 结果 三组女工EFL的发生率较接近 ,约为 30 %～40 % ,但暴露组和内对照组EFL的女工发生率及其周期发生率均高于外对照组 ,且暴露组和内对照组EFL阳性女工的周期发生率显著高于外对照组 (P <0 0 5 )。结论 以低浓度混苯暴露为主的有害因素可能对EFL的发生产生一定影响
Objective To investigate the effect of low concentration mixed benzene exposure on early pregnancy loss (EFL). Methods Forty-two female workers exposed to mixed benzene in a petrochemical enterprise were exposed, 49 were female workers without mixed benzene exposure, 118 were female workers without chemical benzene exposure in a chemical fiber enterprise. Urine samples were collected daily for urine samples from 96, 14 6, and 435 cycles respectively. Urine samples were collected for determination of human chorionic gonadotropin (β) by immunoradiometric assay (IRMA) hCG) content, and early pregnancy loss evaluation. Results The incidence of EFL among the three groups of women workers was similar, ranging from 30% to 40%. However, the incidence and frequency of female workers in EFL group and the control group were higher than those in the external control group, and the exposure group and the control group The incidence of the cycle of EFL-positive female workers was significantly higher than that of the external control group (P <0 05). Conclusions The harmful factors mainly including low benzene and benzene exposure may have some impact on the occurrence of EFL