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目的:探讨IL-17、IL-18在系统性红斑狼疮患者血清中水平的变化及其对该病发病所起的作用。方法:采用双抗体夹心酶联免疫吸附法测定85例系统性红斑狼疮患者、63例其它自身免疫疾病患者和52例健康者血清中IL-17、IL-18的水平。结果:系统性红斑狼疮组患者血清中IL-17水平明显高于健康对照组,差异有统计学意义(P<0.05),与其他自身免疫病组则无明显差异。系统性红斑狼疮组患者血清中IL-18水平明显高于健康对照组及其它自身免疫病组,差异有统计学意义(P<0.01)。结论:IL-17、IL-18在系统性红斑狼疮发病过程中可能起到一定的作用。
Objective: To investigate the changes of serum levels of IL-17 and IL-18 in patients with systemic lupus erythematosus and its role in the pathogenesis of the disease. Methods: Serum levels of IL-17 and IL-18 in 85 patients with systemic lupus erythematosus, 63 patients with other autoimmune diseases and 52 healthy controls were measured by double antibody sandwich enzyme-linked immunosorbent assay. Results: Serum levels of IL-17 in patients with systemic lupus erythematosus were significantly higher than those in healthy controls (P <0.05), but no significant difference with other autoimmune diseases. Serum levels of IL-18 in patients with systemic lupus erythematosus were significantly higher than those in healthy controls and other autoimmune diseases groups (P <0.01). Conclusion: IL-17 and IL-18 may play a role in the pathogenesis of systemic lupus erythematosus.