类风湿性关节炎(RA)是与自身抗体和免疫复合物(IC)有关的自身免疫性疾病。患者关节滑液和血清中的循环免疫复合物(CIC),其含量和种类与疾病的活动程度密切相关。IC中的抗体可是IgG、IgA、IgM或IgE。不同类型CIC的检出,对RA的诊断、治疗、病情观察、判断预后均具有指导意义。本文采用先进的速率散射比浊法,分别测定了76例RA患者血清CIC中IgG、IgA、IgM含量和血清IgG、IgA、IgM含量,并计算CIC中各类Ig的比值,现将结果报告如下。 Rheumatoid arthritis (RA) is an autoimmune disease associated with autoantibodies and immune complexes (ICs). Circulating immune complexes (CICs) in synovial fluid and serum of patients are closely related to the level and activity of the disease. The antibody in the IC can be IgG, IgA, IgM or IgE. Detection of different types of CIC, the diagnosis of RA, treatment, disease observation, prognosis are of guiding significance. In this paper, advanced rate nephelometry was used to determine the serum levels of IgG, IgA, IgM and serum IgG, IgA, IgM in 76 patients with RA, and to calculate the ratio of each Ig in CIC. The results are reported as follows .