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目的探讨鹿瓜多肽注射液致过敏性休克的特点与规律,为临床合理用药提供参考。方法在线检索国内有关医药数据库,下载病例报告原文,统计患者年龄、性别、原患疾病、药物和食物过敏史、给药途径与剂量、发生过敏性休克的时间及临床表现与转归等。结果共检索到鹿瓜多肽注射液致过敏性休克39例。其致过敏性休克的特点与规律是:男性患者占比较高(25例,占64.10%),20~60岁患者占比较高(34例,占87.18%),静脉滴注给药者占比较高(38例,97.44%),首次用药占比较高(36例,占92.31%),静滴开始后30 min内发生者占比较高(35例,占89.74%),过敏性休克的临床症状以呼吸系统(呼吸困难、胸闷)和心血管系统(血压骤降、大汗淋漓)为主。结论鹿瓜多肽注射液引起过敏性休克与性别、原患疾病和给药途径等有关,临床用药须重视过敏史询问、用药过程中不良反应的观察,以及为应对可能出现的过敏性休克先兆症状积极做好抢救准备。
Objective To investigate the characteristics and rules of anaphylactic shock induced by Lugua polypeptide injection and to provide a reference for clinical rational drug use. Methods The online medical database was searched in China. The original reports of the cases were downloaded. The patients' age, gender, original disease, history of drug and food allergy, route of administration and dosage, time and clinical manifestation and outcome of anaphylactic shock were searched online. Results A total of 39 cases of anaphylactic shock induced by Lugua polypeptide injection were retrieved. The characteristics and rules of anaphylactic shock are: male patients accounted for a high proportion (25 cases, accounting for 64.10%), 20 to 60 years old accounted for a higher proportion of patients (34 cases, 87.18%), intravenous infusion accounted for more (38 cases, 97.44%) had the highest proportion of first-time medication (36 cases, accounting for 92.31%), and the high proportion of patients (35 cases, 89.74%) within 30 minutes after the start of intravenous infusion had clinical symptoms of anaphylactic shock Respiratory system (dyspnea, chest tightness) and cardiovascular system (sudden drop in blood pressure, sweating) dominated. Conclusion The incidence of anaphylactic shock caused by Lugua polypeptide injection is related to gender, original disease and route of administration. Clinical medication should pay attention to the history of allergy, the observation of adverse reactions during medication, and the response to possible symptoms of anaphylactic shock Actively prepare for rescue.