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[目的]观察胃力康颗粒对实验性胃溃疡大鼠胃组织碱性成纤维细胞生长因子(basic fibroblast growthfactor,bFGF)表达的影响,探讨胃力康颗粒的疗效机制。[方法]大鼠随机分成正常组、模型组、法莫替丁对照组和胃力康治疗组,以Okabe改良法复制实验性胃溃疡大鼠模型,采用RT-PCR检测各组大鼠胃组织bFGF mRNA表达水平。[结果]胃力康治疗组bFGF mRNA表达水平较模型组明显升高,差异有统计学意义(P<0.05)。[结论]胃力康颗粒能上调bFGF mRNA的表达,从而促进溃疡愈合。
[Objective] To observe the effect of Wei-Li-Kang Granule on the expression of basic fibroblast growth factor (bFGF) in gastric tissue of experimental gastric ulcer rats, and to explore the therapeutic mechanism of Wei-Li Granules. [Methods] The rats were randomly divided into normal group, model group, famotidine control group and Wei Likang treatment group. The rat model of experimental gastric ulcer was reproduced by Okabe modified method, and the gastric tissue bFGF mRNA expression level. [Result] The expression of bFGF mRNA in Wei Li Kang group was significantly higher than that in model group (P <0.05). [Conclusion] Wei Li Kang particles can up-regulate the expression of bFGF mRNA and promote ulcer healing.