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目的:探讨急性淋巴性白血病(ALL)患者血浆可溶性肿瘤坏死因子受体(sTNFR s)变化及其意义。方法:采用酶联免疫吸附法测定了15例ALL患者血浆sTNFR-Ⅰ和sTNFR-Ⅱ水平及血清肿瘤坏死因子α(TNFα),并以20例正常人作对照。结果:ALL患者血浆sTNFR-Ⅰ,sTNFR-Ⅱ和TNFα水平显著升高,与正常对照组差异有显著性(P<0.01)。结论:由sTN-FR-Ⅰ和sTNFR-Ⅱ介导的sTNFα的异常分泌可能是导致ALL细胞增殖的一个重要因素,该受体的测定可以判断患者的疾病状态,对治疗效果同样有评估作用。
Objective: To investigate the changes of plasma soluble tumor necrosis factor receptor (sTNFR s) in patients with acute lymphoblastic leukemia (ALL) and its significance. Methods: Serum levels of sTNFR-Ⅰ and sTNFR-Ⅱ and serum tumor necrosis factor α (TNFα) were measured by enzyme-linked immunosorbent assay in 15 patients with ALL. Twenty normal controls were used as controls. Results: The plasma levels of sTNFR-Ⅰ, sTNFR-Ⅱ and TNFα in patients with ALL were significantly higher than those in normal controls (P <0.01). CONCLUSIONS: The abnormal secretion of sTNFα mediated by sTN-FR-Ⅰ and sTNFR-Ⅱ may be an important factor that leads to the proliferation of ALL cells. The determination of this receptor can judge the disease status of patients and has the same therapeutic effect.