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目的 :研究 β -内啡肽 ( β -EP)对呼吸功能的影响及其与呼吸衰竭发生机制的关系。方法 :选择慢性阻塞性肺疾病患者 63例 ,分为呼吸衰竭组 3 1例 ,非呼吸衰竭组 3 2例 ,分别监测 β -EP及动脉血气分析。结果 :呼吸衰竭组 β -EP值显著高于非呼吸衰竭组 (P <0 0 5 ) ,呼吸衰竭组血浆 β -EP值与PaO2 呈负相关 ,与PaCO2 呈正相关。结论 :β -EP是一种内源性呼吸抑制剂 ,影响呼吸功能 ,参与了呼吸衰竭的发生发展过程。
Objective: To study the effect of β-endorphin (β-EP) on respiratory function and its relationship with the pathogenesis of respiratory failure. Methods: Sixty-three patients with chronic obstructive pulmonary disease were selected and divided into respiratory failure group (n = 31) and non-respiratory failure group (n = 32). Β-EP and arterial blood gas were analyzed respectively. Results: The β-EP value of respiratory failure group was significantly higher than that of non-respiratory failure group (P <0.05). The plasma β-EP value of respiratory failure group was negatively correlated with PaO2 and positively correlated with PaCO2. Conclusion: β-EP is an endogenous respiratory inhibitor, which affects respiratory function and participates in the development of respiratory failure.