论文部分内容阅读
研究了２－取代－１－正丁基－５－苯基－３－吡唑烷酮类化合物的合成和抗惊厥作用，共合成了５个３－吡唑烷酮类新化合物．药理实验结果表明，５个化合物均有较好的抗惊厥活性，其中２－肉桂酰基－１－正丁基－５－苯基－３－吡唑烷酮活性高于先导化合物１－正丁基－５－苯基－３－吡唑烷酮．
The synthesis and anticonvulsant effects of 2-substituted-1-n-butyl-5-phenyl-3-pyrazolidinones were studied. A total of 5 new 3-pyrazolidone compounds were synthesized. The results of pharmacological experiments showed that all the five compounds had good anticonvulsant activity. The activity of 2-cinnamoyl-1-n-butyl-5-phenyl-3-pyrazolidone was higher than that of the precursor 1-n-butyl -5-phenyl-3-pyrazolidone.