Thyroid-stimulating hormone(TSH)-secreting pituitary adenoma is a rare type in all pituitary tumors.Recently we treated a TSH-secreting pituitary tumor in our hospital.The patient had been treated for hyperthyroidism,in which methimazole had been prescribed for 10 years,but the symptoms had not been alleviated.MRI imaging demonstrated the typical features of a sellar tumor,and the diameter was approximately 2.7 cm.Based on the laboratory studies:T3 at 6.27 nmol/L,T4 at 260.10 nmol/L,FT3 at 17.22 pmol/L,FT4 at 76.06 pmol/L,TSH at 9.93 Mu/L,the patient was diagnosed with a TSH-secreting pituitary tumor and central hyperthyroidism.After the patient was given octreotide for one week,he received resection of tumor via single-nostril transsphenoidal approach.After discharge,the patient received the radiation therapy two courses about 20 days.Through the comprehensive treatment of surgery,radiotherapy and drugs,the patient received a satisfactory result. Thyroid-stimulating hormone (TSH) -secreting pituitary adenoma is a rare type in all pituitary tumors. Reciprocally we treated a TSH-secreting pituitary tumor in our hospital. The patient had been treated for hyperthyroidism, in which methimazole had been prescribed for 10 years , but the symptoms had not been alleviated. MRI imaging demonstrated the typical features of a sellar tumor, and the diameter was approximately 2.7 cm. Based on the laboratory studies: T3 at 6.27 nmol / L, T4 at 260.10 nmol / L, FT3 at 17.22 pmol / L, FT4 at 76.06 pmol / L, TSH at 9.93 Mu / L, the patient was diagnosed with a TSH-secreting pituitary tumor and central hyperthyroidism. After the patient was given octreotide for one week, he received resection of tumor via single-nostril transsphenoidal approach. After discharge, the patient received the radiation therapy two courses about 20 days. Through the comprehensive treatment of surgery, radiotherapy and drugs, the patient received a satisfactory result.