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检测哮喘患儿血浆亚硝酸根／硝酸根（ＮＯ２－／ＮＯ３－）和血清肿瘤坏死因子α（ＴＮＦα）含量，并分析其相关关系。结果：正常对照组ＴＮＦα、ＮＯ２－／ＮＯ３－含量分别为（１６４．８５±３１．０８）ｎｇ／Ｌ和（２９．５４±１４．４３）μｍｏｌ／Ｌ；哮喘发作组分别为（１９８．７６±４２．０６）ｎｇ／Ｌ和（４６．６７±１９．１）μｍｏｌ／Ｌ，明显高于对照组（Ｐ＜０．０１），呈显著正相关（Ｐ＜０．０１）；哮喘缓解组为（１９２．４１±３９．５）ｎｇ／Ｌ和（３２．４±１４．９３）μｍｏｌ／Ｌ，ＴＮＦα高于对照组（Ｐ＜０．０５），ＮＯ２－／ＮＯ３－低于发作组（Ｐ＜０．０１）。提示ＴＮＦα和一氧化氮（ＮＯ）可能参与哮喘发作期气道炎症的形成，ＴＮＦα在缓解期的慢性炎症持续中具有重要意义
Plasma nitrite / nitrate (NO2- / NO3-) and serum tumor necrosis factor-α (TNFα) levels in asthmatic children were measured and their correlations were analyzed. Results: The levels of TNFα and NO2- / NO3- in the normal control group were (164.85 ± 31.08) ng / L and (29.54 ± 14.43) μmol / L, respectively. The asthma attack group were (198.76 ± 42.06 ng / L and 46.67 ± 19.1 μmol / L, respectively, which were significantly higher than those in the control group (P <0.01) (192.41 ± 39.5) ng / L and (32.4 ± 14.93) μmol / L, respectively, TNFα was higher than that of the control group (P <0.05), NO2- / P <0.01). It is suggested that TNFα and nitric oxide (NO) may be involved in the formation of airway inflammation during asthma attack, and TNFα may play an important role in the continuation of chronic inflammation during remission