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荷兰研究人员分别给白介素 10 (IL 10 )基因缺陷型小鼠 (IL 10 - /- )和 IL 10基因表现型小鼠 (IL 10 +/+)腹腔注射大肠杆菌 ,造成腹膜炎和脓毒症 ,研究内源性 IL 10在局部细菌感染和全身炎症反应中的作用。研究结果显示 ,2组小鼠腹膜炎和脓毒症的严重程度均与腹腔液及血清中细
Dutch researchers injected E. coli intraperitoneally with interleukin 10 (IL 10) gene-deficient mice (IL 10 - / -) and IL 10 gene-expressing mice (IL 10 + / +), causing peritonitis and sepsis, To investigate the role of endogenous IL-10 in local bacterial infection and systemic inflammatory response. The results showed that the severity of peritonitis and sepsis in both groups was similar to that in peritoneal fluid and serum