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Background: Inequality in degree of extrapyramidal side effects (EPS) caused by antipsychotic drugs is due to that nigrostriate dopamine(DA) system is blocked by drugs,then the activity of acetylcholine(Ach) is relatively stimulated.The application of Anticholinergic agent can keep the relative equilibration between DA and Ach,then relieves or obliterates EPS.When part of patients are undertaking the antipsychotic drugs of antipsychotic drugs,they offen use artane simultaneously.Especially chronically sick persons, whether they need necessarily the application of anticholinergic agent long term or not,and we do some relatetive analysis on that.