MDI是聚氨酯的重要合成原料,职业接触可致哮喘、过敏性肺炎等。其致病机制至今尚无令人满意的解释。为进一步探讨MDI免疫学致病机制,本文选择34只豚鼠,随机分为4组,分别吸入1.06、0.67、0.46和Oppm MDI12天,每天2小时。实验第21天,分别测其腹腔肥大细胞和嗜碱细胞组胺释放率、全血及肺组胺含量和肺环核苷酸含量。结果 MDI is an important synthetic polyurethane raw materials, occupational exposure can cause asthma, allergic pneumonia. Its pathogenesis has so far not been satisfactorily explained. To further explore the pathogenesis of MDI immunology, this paper choose 34 guinea pigs were randomly divided into 4 groups, respectively, inhaled 1.06,0.67,0.46 and Oppm MDI12 days, 2 hours a day. On the 21st day of the experiment, the peritoneal mast cells and basophils histamine release rate, whole blood and lung histamine content and pulmonary cyclic nucleotide content were measured. result