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氨噻肟头孢菌素(Cefotaxime,CTX)为第三代头孢菌素,尚未有报告提及CTX引起腹泻者。作者报告一例类风湿性关节炎患者,因应用CTX引起艰难梭菌(Clostridium diffic(?)le)性肠炎。患者为一例48岁女性,有10年类风湿性关节炎病史,因干咳、气短、发热(达39℃)一个月于1982年9月3日入院。胸部摄片及肺活检诊断为类风湿性关节炎所致之间质性肺炎,遂投用强的松龙,从每日60mg开始,逐渐减量,经10周减至维持量每日25mg,患者之临床及胸部x线表现明显改善,此后一直无发热。至12月5日体温升至38.9℃,有寒战,虽然当时临床上没有感染或类风湿性
Cefotaxime (Cefotaxime, CTX) is the third generation cephalosporin, no report has mentioned CTX cause diarrhea. The authors report a case of rheumatoid arthritis in which CTX causes Clostridium difficileitis. The patient, a 48-year-old woman with a 10-year history of rheumatoid arthritis, was admitted to hospital on September 3, 1982 for one month for dry cough, shortness of breath, and fever (up to 39 ° C). Chest radiography and lung biopsy diagnosis of interstitial pneumonia caused by rheumatoid arthritis, then cast prednisolone, starting from the daily 60mg, tapering, reduced to maintain the amount of 10mg by 10 weeks daily 25mg, The patient’s clinical and chest x-ray performance improved significantly, since then there is no fever. To December 5 body temperature rose to 38.9 ℃, chills, although there was no clinical or rheumatoid