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目的 观察地佐辛注射液对老年结肠癌患者手术后炎症因子、超氧化物歧化酶(SOD)及T淋巴细胞影响.方法将90例择期进行结肠癌腹腔镜手术的老年患者随机分为对照组45例和试验组45例.对照组给予1.5％ ～ 3.0％七氟醚持续吸入,瑞芬太尼4μg.kg-1 ·h-1静脉滴注;试验组给予1.5％ ～3.0％七氟醚持续吸入,地佐辛40 μg·kg-1·h-1静脉滴注.观察2组患者的肿瘤坏死因子-α(TNF-0)、白细胞介素-6(IL-6)、SOD、丙二醛(MDA)、T淋巴细胞亚群水平及药物不良反应发生情况.结果 术后24h,试验组和对照组的TNF-α分别为(16.28±3.21),(18.67±3.54) pg·I-1,SOD分别为(97.82±7.03),(94.48±6.45)nU·mL-1,MDA分别为(4.10±0.54),(4.72±0.61) mmol·L-1,CD3+分别为(69.35±2.53)％,(68.01±2.23)％,差异均有统计学意义(均P ＜0.05).试验组和对照组的镇静评分分别为(2.54±0.66),(1.48±0.45)分,疼痛评分分别为(1.49±0.37),(3.20±0.59)分,差异均有统计学意义(均P＜0.05).对照组发生的药物不良反应以嗜睡、皮肤瘙痒和恶心呕吐为主,试验组发生的药物不良反应以嗜睡和恶心呕吐为主;试验组和对照组的药物不良反应发生率均为13.33％,差异无统计学意义(P＞0.05).结论地佐辛注射液可有效降低老年结肠癌腹腔镜手术患者的免疫抑制,改善氧化应激反应,促进术后恢复,且安全性高.“,”Objective To observe the effect of dezocine injection in in flammatory factors,superoxide dismutase (SOD) and T lymphocytes of elderly patients after colon cancer surgery.Methods A total of 90 elderly patients who underwent laparoscopic surgery for colon cancer were randomly divided into control group with 45 cases and treatment group with 45 cases.The control group received 1.5％ to 3.0％ sevoflurane continuous inhalation,remifentanil 4 μg · kg-1 · h-1 iv,and treatment group received 1.5％ to 3.0％ sevoflurane continuous inhalation,dezocine 4 μg · kg-1 · h-1 iv.Tumor necrosis factor-α (TNF-α),interleukin-6 (IL-6),SOD,malondialdehyde (MDA) and T lymphocyte subsets,the incidence of adverse drug reactions in two groups were compared.Results At 24 h after operation,the TNF-α in treatment group and control group were (16.28 ± 3.21),(18.67 ±3.54)pg · L-1,SOD were (97.82 ±7.03),(94.48 ±6.45)nU · mL-1,MDA were respectively(4.10 ±0.54) and (4.72 ±0.61) mmol · L-1,CD3 + were(69.35 ± 2.53)％and (68.01 ± 2.23)％,all with significant difference (all P ＜ 0.05).The sedation scores in treatnent group and control group were (2.54 ± 0.66) and (1.48 ± 0.45) points,the pain scores were (1.49 ± 0.37) and (3.20 ± 0.59)points,with significant difference (all P ＜ 0.05).The adverse drug reactions in control group were mainly drowsiness,pruritus and nausea and vomiting.The adverse drug reactions in treatment group were drowsiness,nausea and vomiting,the incidence of adverse drug reactions in two groups were 13.33％,13.33％,with no significant difference (P ＞ 0.05).Conclusion Dezocine injection can reduce immunosuppression in elderly patients with colorectal cancer under laparoscopic surgery,improve oxidative stress,promote postoperative recovery with high safety.