氢化可的松口服制剂的血药浓度与剂量不呈正比,曾被归因于片剂效应、或非线性吸收及首过代谢作用。本文进一步研究氢化可的松口服制剂药物动力学参数与剂量间的关系。8例健康男性受试者口服5、10、20、40mg四种不同剂量的氢化可的松混悬剂(受试者预服2mg地塞米松以消除内源性化合物对血药浓度正确测定的干扰)。服药后12小时内取血样,提取制备,用 The plasma concentration of hydrocortisone oral formulations is not proportional to the dose, has been attributed to the tablet effect, or non-linear absorption and first-pass metabolism. This article further studies hydrocortisone oral pharmacokinetic parameters and the relationship between dose. Eight healthy male subjects were orally given 4, 10, 20, and 40 mg of hydrocortisone suspension at 4 different doses (subject was pre-treated with 2 mg of dexamethasone to eliminate endogenous compounds that were correctly determined for plasma concentrations interference). Within 12 hours after taking the blood samples, extraction preparation, use