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目的：探讨雄激素对尿石症患者的影响。方法：用体积分数为０．５％乙二醇诱导结石形成；建立４组动物实验雄鼠模型。Ａ组：去势结石组；Ｂ组：去势加皮下注射睾丸酮（３ｍｇ／ｄ）结石组；Ｃ组：结石对照组；Ｄ组：正常对照组（标准无结石饮食）。４组雄鼠饲养４周后同时宰杀，分别测定和比较他们血清Ｔｅｓｔｏ，ＦＳＨ，ＬＨ，Ｅ２，ＰＲＬ，Ｐｒｏｇ；单侧肾质量，肾内钙、镁、磷含量。结果：Ｂ组肾内钙含量明显高于Ａ组。结论：雄性激素对尿石症有一定影响，它能增加实验鼠肾组织内钙的沉积。
Objective: To investigate the effect of androgens on patients with urolithiasis. Methods: The volume fraction of 0.5% ethylene glycol induced calculus formation; established four groups of animal experimental male model. Group A: castrated stone group; Group B: castration plus subcutaneous injection of testosterone (3mg / d) stone group; group C: stone control group; group D: normal control group (standard non-stone diet). Four groups of male rats were slaughtered at the same time for 4 weeks, and their serum Testo, FSH, LH, E2, PRL and Prog were measured and compared. The unilateral kidney weight, renal calcium, magnesium and phosphorus contents were measured. Results: The renal calcium content in group B was significantly higher than that in group A. Conclusion: Androgens have a certain effect on urolithiasis, which can increase the deposition of calcium in the kidney of rats.