糖尿病肾病(DN)是糖尿病的严重慢性并发症之一,目前已成为终末期肾病及糖尿病死亡率增加的重要因素.DN发病机制较复杂,涉及多种因素共同作用.以干细胞为基础的再生医学为DN的治疗带来新的希望.其中间充质干细胞(MSCs)改善DN发展的作用机制受到越来越多的关注,就MSCs通过旁分泌作用改善DN作一综述.“,”Diabetic nephropathy (DN) is one of the severe chronic complications of diabetes,and has become an important contributing factor of end-stage renal disease and increased mortality of diabetes.DN pathogenesis is complicated,involving many factors working together.Regenerative medicine based on stem cells for the treatment of DN brings new hope.The mechanism of mesenchymal stem cells (MSCs) improving DN development get more and more attention,in this paper,we will talk about MSCs in improving DN through paracrine effect,hope it will provide the new mentality for the treatment of DN.