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鉴于碳酸锂治疗精神病往往发生粒细胞增多症。近来有用碳酸锂预防癌肿治疗中引起嗜中性粒细胞减少的报告。倘若用锂治疗嗜中性粒细胞减少症有效,则有必要研究锂治疗后病人的细胞功能。因此,作者应用试管法研究了接受锂治疗病人的嗜中性粒细胞的几种功能及正常志愿者的细胞在试管内接触氯化锂后的功能的研究。研究对象为5例锂治疗的精神郁忧症的病人,女4人,男1人,年龄20～50岁,研究前已用锂治疗8周以上。剂量为0.68～1.7克/天,(平均1.2±0.21克/天),血清锂的浓度0.68～1.7mEq/L,
In view of lithium carbonate treatment of mental illness often occurs agranulocytosis. Recent use of lithium carbonate to prevent neoplasia in cancer therapy report. If lithium is effective in treating neutropenia, it is necessary to study the cellular function of the patient after lithium treatment. Therefore, the authors used the test tube method to study several functions of neutrophils in lithium-treated patients and the function of normal volunteer cells after exposure to lithium chloride in vitro. The subjects were 5 patients with mental depression caused by lithium therapy, 4 were female and 1 male, aged 20 to 50 years old. Lithium was used for more than 8 weeks before the study. Dose ranged from 0.68 to 1.7 g / day, (mean 1.2 ± 0.21 g / day), serum lithium concentration from 0.68 to 1.7 mEq / L,