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目的:观察针刺和耳压联合微生态制剂治疗IBS患者的临床疗效及探讨对胃肠激素VIP、NPY水平影响。方法:126例患者随机分为A组42例,采用针刺和耳压联合微生态制剂治疗;B组43例,采用针刺和微生态制剂治疗;C组41例,采用单纯针刺治疗,疗程结束后观察和评价患者疗效情况、复发率、以及治疗前后血浆VIP、NPY水平变化。结果:A组疗效优于B组、C组(P<0.05,P<0.01),且复发率低;B组疗效亦优于C组(P<0.05)。A、B两组治疗后血浆VIP、NPY水平与治疗前相比均有显著性差异(P<0.05)。结论:针刺和耳压联合微生态制剂的综合疗法能有效治疗IBS,且疗效相对稳定,能够恢复IBS胃肠激素分泌异常情况。
Objective: To observe the clinical efficacy of acupuncture and otolae injection combined with probiotics in the treatment of patients with IBS and to explore the effects on the levels of VIP and NPY of gastrointestinal hormones. Methods: 126 patients were randomly divided into group A (n = 42), acupuncture and otolae injection combined with probiotics. Group B (n = 43) was treated with acupuncture and probiotics. Group C (n = 41) After treatment, the curative effect and recurrence rate of patients were observed and evaluated, and the changes of plasma VIP and NPY levels before and after treatment were also observed. Results: The efficacy of group A was better than that of group B and group C (P <0.05, P <0.01), and the recurrence rate was lower. The efficacy of group B was also better than that of group C (P <0.05). The levels of plasma VIP and NPY in groups A and B after treatment were significantly different from those before treatment (P <0.05). Conclusion: Combination therapy of acupuncture and otolae injection combined with probiotics can effectively treat IBS with relatively stable curative effect and can restore abnormal secretion of gastrointestinal hormones in IBS.