胰岛素原（ＰＩ）于１９８２年由美国Ｌｉｌｙ公司研究所首次应用ＤＮＡ重组技术在生物合成人胰岛素中，同时合成的人胰岛素原（ＨＰＩ）经动物试验与临床观察证明有降血糖作用，从而引起关注，在国际研究领域中对ＰＩ进行了多项观察。１胰岛素原降糖作用与临床应用ＰＩ是... Proinsulin (PI) was first used in 1982 in the biosynthesis of human insulin by the Lily Institute of the United States, and the synthetic human proinsulin (HPI) has been shown to have hypoglycemic effects by animal and clinical observations, resulting in concern , In the field of international research conducted a number of PI observations. 1 proinsulin hypoglycemic effect and clinical application PI is ...