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615近交系小鼠自发性肿瘤已经建立的模型有淋巴性白血病、乳腺癌、肺腺癌、肝细胞性肝癌等,但至今文献中未见报道615小鼠自发的或诱发的皮下恶性纤维组织细胞瘤(Malignant fibrous histiocytoma,MFH)的动物模型。我们于1980年12月用甲基胆蒽诱发了615近交系小鼠皮下恶性纤维组织细胞瘤,并在同系小鼠移植成功,经传26代,建成了可移植性MFH-615模型。该模型移植成功率高(92.4％),未见自然消退,转移率较高,组织形态与人的MFH相似。本模型的建成为实验肿瘤学研究提供了
615 inbred mice spontaneous tumor has been established in the model of lymphoid leukemia, breast cancer, lung adenocarcinoma, hepatocellular carcinoma, but so far no literature reported 615 mice spontaneous or induced subcutaneous malignant fibrous tissue Animal model of Malignant fibrous histiocytoma (MFH). In December 1980, we induced 615 inbred mice subcutaneous malignant fibrous histiocytoma with methylcholanthrene, and successfully transplanted it in the same line mice. After passage for 26 passages, we constructed the transplantable MFH-615 model. The success rate of transplantation was high (92.4%). No spontaneous regression and high metastatic rate were observed. The morphology of the model was similar to that of human MFH. The establishment of this model provided experimental oncology research