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目的探讨M2型巨噬细胞与食管鳞状细胞癌(ESCC)淋巴结转移、临床分期和T分期之间的相关性。方法检索PubMed和EMBASE数据库,最终纳入6篇文献1 318例食管癌组织标本进行Meta分析。分析指标包括淋巴结转移、临床分期和T分期。结果食管癌组织中M2型巨噬细胞浸润密度与淋巴结转移(OR=3.39,95%CI=2.92~3.94,P<0.000 01)和临床分期(OR=5.01,95%CI=4.22~5.93,P<0.000 01)明显相关,与T分期无明显相关(OR=0.89,95%CI=0.66~1.20,P=0.44)。结论食管癌组织中M2型巨噬细胞浸润与淋巴结转移及与临床分期具有统计学意义的相关性,提示其细胞浸润可作为ESCC淋巴结转移及临床分期的一个预测标志物。
Objective To investigate the correlation between M2 macrophages and lymph node metastasis, clinical stage and T stage in esophageal squamous cell carcinoma (ESCC). Methods The PubMed and EMBASE databases were searched. Finally, 1 318 samples of esophageal cancer tissues from 6 literatures were included in the meta-analysis. Analysis of indicators, including lymph node metastasis, clinical stage and T staging. Results The density of type M2 macrophages in esophageal cancer was significantly correlated with lymph node metastasis (OR = 3.39, 95% CI = 2.92-3.94, P <0.000 01) and clinical stage (OR = 5.01, 95% CI = 4.22-5.93, P <0.000 01), but no significant correlation with T stage (OR = 0.89, 95% CI = 0.66-1.20, P = 0.44). Conclusions There is a statistically significant correlation between the type M2 macrophage infiltration and lymph node metastasis and clinical stage in esophageal cancer tissues, suggesting that cell infiltration may serve as a predictive marker of lymph node metastasis and clinical stage in ESCC.