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目的探讨先兆流产患者绒毛膜促性腺激素(β-HCG)与游离β亚单位(fβ-HCG)及黄体酮含量(Progesterone,P)的表达及意义。方法先兆流产患者50例,设为观察组,正常早孕妇女50例为对照组,采用化学发光分析法对两组研究对象血样进行β-HCG、fβ-HCG、P含量的检测,每隔48 h对研究对象进行同样条件下的β-HCG、fβ-HCG、P含量的检测。48 h倍增率=(48 h测定值-初测值)÷初测值。结果β-HCG、P含量组间比较差异无统计学意义(P>0.05),fβ-HCG含量观察组显著高于对照组,差异有统计学意义(P<0.05)。β-HCG、fβ-HCG 48 h倍增率比较,差异无统计学意义(P>0.05)。结论检测并综合分析β-HCG、fβ-HCG及黄体酮在先兆流产中的表达,对判断妊娠结局具有参考价值。
Objective To investigate the expression and significance of human chorionic gonadotropin (β-HCG), free β subunit (β-HCG) and progesterone (P) in patients with threatened abortion. Methods Thirty patients with threatened abortion were enrolled in the observation group and 50 normal pregnant women as the control group. The levels of β-HCG, fβ-HCG, and P were determined by chemiluminescence analysis. The subjects were tested under the same conditions of β-HCG, fβ-HCG, P content. 48 h multiplication rate = (48 h measured value - initial test value) ÷ initial test value. Results There was no significant difference between the groups of β-HCG and P (P> 0.05). The content of fβ-HCG in the observation group was significantly higher than that of the control group (P <0.05). β-HCG, fβ-HCG 48 h multiplication rate, the difference was not statistically significant (P> 0.05). Conclusion The detection and comprehensive analysis of β-HCG, fβ-HCG and progesterone expression in threatened abortion may be of reference value in judging pregnancy outcome.