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控制食管曲张静脉出血的理想方法是一种能迅速而有效地降低门脉及曲张静脉压的药物,且无全身副反应。硝酸甘油能降低门脉压,而胃复安可增加下食管括约肌压力,减少奇静脉血流量。此两药降低曲张静脉压的机理不同。为评价这两种药物联合应用对曲张静脉压的影响并观察大剂量硝酸甘油(300μg)的作用和安全性而进行本研究。 病人和方法 选择病人标准为:(1)过去有曲张静脉出血史,(2)未用过硬化剂和其他药物治疗曲张静脉出血,(3)无肝性脑病、腹水或
An ideal method of controlling variceal bleeding is a rapid and effective drug that reduces portal and varicose vein pressures without systemic side effects. Nitroglycerin can reduce portal pressure, and metoclopramide can increase the pressure of the lower esophageal sphincter to reduce odd venous blood flow. The mechanism of the two drugs to reduce varicose vein pressure is different. This study was conducted to evaluate the effect of combination of these two drugs on varicose vein pressure and to observe the effect and safety of high-dose nitroglycerin (300 μg). Patients and Methods Patients were selected for the following criteria: (1) history of variceal bleeding in the past, (2) bleeding of varicose veins without the use of sclerosing agents and other medications, (3) absence of hepatic encephalopathy, ascites or