肝细胞生长因子或肝细胞增殖原是一些可刺激肝细胞增殖的生物性、营养性和化学性物质。证实并了解肝细胞增殖原的作用对肝病学十分重要。过去十年的研究有力地提示,循环血中至少有三种肽—胰岛素、高血糖素和表皮生长因子—在生理上刺激肝细胞增殖;并支持协同的体液作用控制着肝细胞增殖的假说。成体肝细胞基本是“静止的”,只含微量M期肝细胞(1/2000)和少量S期肝细胞 Hepatocyte growth factor or hepatocyte proliferation is a number of primitive biological, nutritional and chemical substances that stimulate the proliferation of hepatocytes. It is important for hepatology to confirm and understand the role of hepatoproliferation. Research over the past decade has strongly suggested that circulating blood has at least three peptides, insulin, glucagon and epidermal growth factor, that physiologically stimulate hepatocyte proliferation and support the hypothesis that synergistic humoral effects control hepatocyte proliferation. Adult hepatocytes are essentially “quiescent,” containing only trace amounts of M-phase hepatocytes (1/2000) and a small amount of S-phase hepatocytes