论文部分内容阅读
作者以可识别人结肠癌相关抗原的单克隆抗体SC13A为探针，对卵巢原发肿瘤和继发肿瘤进行免疫组化研究（SP法）。试图区别卵巢原发、继发肿瘤间是否存在不相同的抗原决定簇，探讨其在鉴别卵巢原发与继发肿瘤中的诊断价值。结呆是原发恶性卵巢肿瘤的抗原表达率为6％（3／52），与继发性卵巢肿瘤的抗原表达率88％（23／26）相比较，存在明显差异，有极显著性意义（P＜0．001）。在继发性卵巢肿瘤中，胃肠道源的转移癌其抗原表达率100％（n＝23），而来源于生殖道的子宫体转移癌无抗原表达（n＝3）。提示卵巢原发肿瘤与胃肠道转移肿瘤间具有不相同的抗原决定簇，并可对鉴别原发与继发性卵巢癌的诊断有较重要的临床意义。
The authors used monoclonal antibody SC13A, which recognizes human colon cancer-associated antigen, as a probe to perform immunohistochemical studies on ovarian primary tumors and secondary tumors (SP method). Trying to distinguish between the primary and secondary ovarian tumors for the presence of different antigenic determinants, to explore its diagnostic value in the identification of primary and secondary ovarian tumors. The rate of antigen expression in primary malignant ovarian tumors was 6% (3/52), and compared with 88% (23/26) of antigen expression in secondary ovarian tumors, there was a significant difference, with extremely significant significance. (P<0.001). In secondary ovarian tumors, the GI-derived metastatic carcinoma showed an antigen expression rate of 100% (n=23), whereas the uterine metastatic carcinoma derived from the genital tract had no antigen expression (n=3). It suggests that there are different antigenic determinants between primary ovarian tumors and metastatic tumors in the gastrointestinal tract, and may have important clinical significance in the diagnosis of primary and secondary ovarian cancers.