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近年来认为NK细胞具有生理性免疫调节功能,因而日益引起人们的重视.本文仅就NK细胞对B细胞功能的调节作用作一简单综述.一、NK细胞对B细胞活性的影响(一)活化NK细胞对B细胞功能的影响NK细胞除具有自发性细胞毒作用外,还能被卡介苗、干扰素(IFN)、干扰素诱导剂、IL-2、某些肿瘤细胞及某些尚未确定的因子激活,称为活化NK细胞.活化的NK细胞能杀伤某些对非活化状态的NK细胞有相对抵抗的靶细胞.在病理情况下,被IFN激活的NK细胞在体外能溶解人来源于B细胞的白血病细
In recent years, NK cells are thought to have physiological immunomodulatory function, which is attracting more and more attention.This paper only briefly reviews the regulatory function of NK cells on B cell function.First, NK cells affect the activity of B cells (A) Activation NK cells on the B cell function NK cells in addition to spontaneous cytotoxicity, but also by BCG, interferon (IFN), interferon inducer, IL-2, some tumor cells and some of the undetermined factor Activation, called activated NK cells, activates NK cells that kill certain target cells that are relatively resistant to non-activated NK cells.Pathologically, IFN-activated NK cells can lyse humans from B cells in vitro Leukemia fine