探讨丹参酮ⅡＡ磺酸钠（Ｔａｎ）对培养人脐静脉内皮细胞（ＨＵＶＥＣ）和人血小板表达粘附分子的影响．方法：用流动血细胞计数仪测定肿瘤坏死因子（ＴＮＦα）诱导人脐静脉内皮细胞ＩＣＡＭ１和凝血酶诱导人血小板Ｐ选择素的表达．结果：ＨＵＶＥＣ经ＴＮＦα处理后，明显增加细胞表面ＩＣＡＭ１的表达，增加ＨＬ６０细胞粘附到内皮细胞表面达加入细胞总数的３０％±６％（对照组为４６％±０７％）．在ＴＮＦα处理前，用Ｔａｎ（２５－２００μｍｏｌ·Ｌ－１）与ＨＵＶＥＣ共孵育，则Ｔａｎ剂量依赖性地抑制ＴＮＦα的作用．Ｔａｎ（２５－２００μｍｏｌ·Ｌ－１）与人血小板孵育后，可剂量依赖性地抑制凝血酶诱导人血小板表面Ｐｓｅｌｅｃｔｉｎ的表达．结论：Ｔａｎ可抑制内皮细胞和血小板表达粘附分子． 2. To investigate the effect of tanshinone II - A sulfonate (Tan) on cultured human umbilical vein endothelial cells (HUVEC) and human platelet expression adhesion molecules. METHODS: Flow cytometry was used to determine the expression of human platelet Pselectin induced by tumor necrosis factor (TNFα) induced by ICAM1 and thrombin in human umbilical vein endothelial cells. RESULTS: HUVECs treated with TNFα significantly increased the expression of ICAM1 on the cell surface and increased the adherence of HL60 cells to the surface of endothelial cells to 30%±6% of the total number of added cells (46% in the control group). 07%). Before TNFα treatment, Tan was co-incubated with HUVEC with Tan (25-200 μmol·L-1). Tan inhibited the effect of TNFα in a dose-dependent manner. After incubation with human platelets, Tan (25-200 μmol·L-1) dose-dependently inhibited thrombin-induced Pselectin expression on human platelets. Conclusion: Tan can inhibit the expression of adhesion molecules on endothelial cells and platelets.