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目的:研究胃癌患者围手术期的免疫状态.方法:应用流式细胞仪检测33例胃癌患者手术前后T细胞表面6种细胞表型,并与良性病变患者进行对比分析.结果:胃癌患者术前CD3~+、CD4~++、CD16~+、CD69~+细胞以及CD4~+/CD8~+细胞比值明显低于对照组.CD8~+细胞显著高于对照组(P<0 01),CD3~+/HLA-DR~+细胞与对照组相同;术后CD8~+细胞降低,CD3~+、CD4~+、CD4~+/CD8~+、CD16~+、CD69~+、CD3~+/HLA-DR~+均升高(PM<0.01).CD3~+/HLA-DR~+的活化T细胞明显高于对照组(P<0.01).结论:胃癌患者术前免疫功能低下,术后细胞免疫功能改善,活化T细胞明显增多.
Objective: To study the perioperative immune status of gastric cancer patients. Methods: Flow cytometry was used to detect the 6 cell phenotypes of T cells in 33 gastric cancer patients before and after operation, and compared with benign lesions. Results: Preoperative gastric cancer patients The ratios of CD3~+, CD4~++, CD16~+, CD69~+ cells and CD4~+/CD8~+ cells were significantly lower than those of the control group. The number of CD8~+ cells was significantly higher than that of the control group (P<0 01). ~+/HLA-DR~+ cells were the same as the control group; postoperative CD8~+ cells were decreased, CD3~+, CD4~+, CD4~+/CD8~+, CD16~+, CD69~+, CD3~+/ HLA-DR~+ was elevated (PM<0.01). The number of activated T cells was significantly higher in CD3~+/HLA-DR~+ than in the control group (P<0.01). Conclusion: Preoperative immune function is low in patients with gastric cancer. Cellular immunity improved, and activated T cells increased significantly.