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目的:系统评价尿膀胱癌抗原(urinary bladder cancer,UBC)检测对膀胱癌的诊断意义。方法:制定原始文献的纳入、排除标准及检索策略,检索Pubmed(1996年1月~2014年8月)、EMBase(1996年1月~2014年8月)、CNKI(1996年1月~2014年8月)、万方数据库(1996年1月~2014年8月)、维普数据库(1996年1月~2014年8月),收集UBC检测诊断膀胱癌的有关文献,用MetaDiSc1.4软件进行Meta分析。结果:共检索到相关研究文献53篇,对纳入符合标准的22篇文献进行Meta分析,共3 371人。异质性检验提示无阈值效应,但存在其他原因导致的异质性。用随机效应模型进行Meta分析。UBC检测诊断膀胱癌的敏感度为0.673,特异度为0.827,阳性似然比为3.447,阴性似然比为0.365,诊断优势比为9.993,综合受试者工作特征曲线下面积为0.8271,Q*指数为0.7599。结论:UBC作为一种敏感度、特异性均较高的无创性尿膀胱肿瘤标志物,可以作为膀胱癌诊疗的重要辅助手段,可在今后的膀胱癌防治工作中发挥重要作用。
Objective: To systematically evaluate the diagnostic value of urinary bladder cancer (UBC) in diagnosis of bladder cancer. Methods: To establish the inclusion, exclusion criteria and search strategies of the original documents. Pubmed (January 1996 to August 2014), EMBase (January 1996 to August 2014), CNKI (January 1996 to 2014 August), Wanfang database (January 1996-August 2014), VIP database (January 1996-August 2014), collect the relevant literature of UBC detection and diagnosis of bladder cancer, using MetaDiSc1.4 software Meta analysis. Results: A total of 53 related research papers were retrieved, and a total of 3 371 people were included in the meta-analysis of 22 articles that were included in the criteria. Heterogeneity tests suggest no threshold effects, but there are other causes of heterogeneity. Meta-analysis was performed using a random-effects model. UBC detection of bladder cancer sensitivity was 0.673, specificity was 0.827, positive likelihood ratio was 3.447, negative likelihood ratio was 0.365, diagnostic odds ratio was 9.993, integrated subjects under the operating characteristic curve area of 0.8271, Q * The index is 0.7599. Conclusion: UBC, as a noninvasive urinary bladder tumor marker with high sensitivity and specificity, can be used as an important adjunct to diagnosis and treatment of bladder cancer and plays an important role in the prevention and treatment of bladder cancer in the future.