目的：了解术前局部注射高三尖杉酯碱联合地塞米松对减少翼状胬肉术后复发的效果。方法：将７２例翼状胬肉患者分为两组，治疗组４２例４２眼，术前７、３及１ｄ翼状胬肉局部注射１．８×１０－４ｍｏｌ／Ｌ高三尖杉酯碱０．２ｍＬ加９．６８×１０－３ｍｏｌ／Ｌ地塞米松０．２ｍＬ的混合液共约０．４ｍＬ，对照组３０例３０眼术前不用药。分别观察术后眼部反应、复发率及行增殖细胞核抗原（ＰＣＮＡ）免疫组化研究。结果：平均术后随访１８．２月，术后复发率分别为，治疗组４．７６％（２／４２），对照组２３．３３％（７／３０），二组比较差异有显著性（Ｐ＜０．０５）。病理结果显示，治疗组ＰＣＮＡ阳性率为（５．５９±３．８２）％，对照组阳性率为（１１．５±３．６２）％，二组比较差异有显著性（Ｐ＜０．０５）；二组皆未见毒副作用。结论：术前翼状胬肉局部注射高三尖杉酯碱联合地塞米松可以减少翼状胬肉术后复发率 Objective: To investigate the effect of preoperative local injection of homoharringtonine and dexamethasone on the reduction of postoperative recurrence of pterygium. Methods: Seventy-two patients with pterygium were divided into two groups. The treatment group consisted of 42 patients (42 eyes), and 0.2 × 10-4 mol / L homoharringtonine 0.2 mL Plus 9.68 × 10-3mol / L dexamethasone 0.2mL a total of about 0.4mL mixture of 30 patients in the control group of 30 eyes before surgery without medication. The postoperative ocular response, recurrence rate and immunohistochemistry of proliferating cell nuclear antigen (PCNA) were observed. Results: The mean postoperative follow-up was 18.2 months. The postoperative recurrence rates were 4.76% (2/42) in the treatment group and 23.33% (7/30) in the control group respectively, with significant difference between the two groups P <0.05). The pathological results showed that the positive rate of PCNA was (5.59 ± 3.82)% in the treatment group and (11.5 ± 3.62)% in the control group, the difference was significant (P <0.05) ); Two groups are not seen toxic side effects. Conclusions: Local injection of homoharringtonine and dexamethasone in preoperative pterygium can reduce the recurrence rate of pterygium